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Zoledronic acid


Trade name: ZOLEREN, 188Re
International nonproprietary name: Zoledronic acid
Pharmaceutical form: lyophilisate for preparation of solution for intravenous administration



One vial contains:
Active substance: Zoledronic acid 4.0 mg
Gentisinic acid 2.3 mg
Tin (II) chloride anhydrous or tin (II) chloride dehydrate calculated with reference to tin (II) chloride 1.5 mg
Sodium perrhenate 0.045 mg
1.5М hydrochloric acid solution q.s. up to рН 1.0


  • ZOLEREN, 188Re is indicated for administration as an alternative method or in addition to palliative therapy of the pain syndrome in patients with bone metastases of malignant tumors which tend to metastasize into the skeleton
  • It may also be used in the complex treatment of patients with rheumatoid arthritis and other non-cancer diseases of joints with the severe pain syndrome.



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Lite of life

Tomographic images of a patient after administration of zoledronic acid labeled with rhenium -188 taken during clinical trials in the A. Tsyb Medical Radiological Research Centre. Lighting foci are metastases, in which the radiopharmaceutical agent accumulates.